|
| Status |
Public on Jun 18, 2022 |
| Title |
Targeted degradation of GSPT1 causes TP53-independent cell death in leukemia whilst sparing normal stem cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To investigate the effect of drugs that degrade GSTP1 on leukemia cell biology.
|
| |
|
| Overall design |
We performed RNAseq on MOLM13 cells that were treated with vehicle (DMSO), CC-885, or CC-90009 (CC-663) for 24 hours.
|
| |
|
| Contributor(s) |
Sperling A, Sellar R, Ebert B |
| Citation(s) |
35763353 |
| |
| Submission date |
Jun 15, 2022 |
| Last update date |
Sep 17, 2022 |
| Contact name |
Adam S Sperling |
| E-mail(s) |
adam_sperling@dfci.harvard.edu
|
| Phone |
310-650-3500
|
| Organization name |
Brigham and Women's Hospital
|
| Department |
Hematology
|
| Lab |
Harvard Institutes of Medicine (HIM) 733
|
| Street address |
4 Blackfan Circle
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (6)
|
| GSM6246330 |
MOLM13 cells, CC-885, biol replicate 2 |
| GSM6246331 |
MOLM13 cells, CC-90009 (CC-663), biol replicate 1 |
| GSM6246332 |
MOLM13 cells, CC-90009 (CC-663), biol replicate 2 |
|
| Relations |
| BioProject |
PRJNA849661 |
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