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| Status |
Public on Sep 04, 2022 |
| Title |
BisDemethoxyCurcumin (BDC) loaded H-Ferritin-Nanocages Mediate Regulation of inflammation in Alzheimer’s Disease Patients |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Bisdemethoxycurcumin (BDC) might be inflammation inhibitor in AD. BDC is almost insoluble in water, poorly absorbed by the organism, and rapidly degraded. We developed a nanoformulation of BDC based on H-Ferritin nanocages (HFn).
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| Overall design |
The effect BDC-HFn on AD and control PBMCs was tested to evaluate the transcriptomic profile by RNA-sequencing.
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| Contributor(s) |
Gagliardi S, Truffi M, Tinelli V, Garofalo M, Pandini C, Cotta Ramusino M, Perini G, Costa A, Negri S, Mazzucchelli S, Arianna B, Mazzucchelli S, Sitia L, Busacca M, Sevieri M, Ricciardi A, Prosperi D, Corsi F, Cereda C, Morasso C |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
May 19, 2022 |
| Last update date |
Sep 06, 2022 |
| Contact name |
Maria Garofalo |
| E-mail(s) |
maria.garofalo01@universitadipavia.it
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| Organization name |
IRCCS Mondino Foundation
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| Lab |
Genomic and Post Genomic Unit
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| Street address |
Via Mondino 2
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| City |
Pavia |
| ZIP/Postal code |
27100 |
| Country |
Italy |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (23)
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| GSM6171492 |
AD patient, PBMCs untreated 4 |
| GSM6171493 |
Control, PBMCs untreated 1 |
| GSM6171494 |
Control, PBMCs untreated 3 |
| GSM6171495 |
Control, PBMCs untreated 4 |
| GSM6171496 |
AD patient, PBMCs treated with HFn-BDC 1 |
| GSM6171497 |
AD patient, PBMCs treated with HFn-BDC 2 |
| GSM6171498 |
AD patient, PBMCs treated with HFn-BDC 3 |
| GSM6171499 |
AD patient, PBMCs treated with HFn-BDC 4 |
| GSM6171500 |
Control, PBMCs treated with HFn-BDC 1 |
| GSM6171501 |
Control, PBMCs treated with HFn-BDC 2 |
| GSM6171502 |
Control, PBMCs treated with HFn-BDC 3 |
| GSM6171503 |
Control, PBMCs treated with HFn-BDC 4 |
| GSM6171504 |
AD patient, PBMCs treated with HFn-Cur 1 |
| GSM6171505 |
AD patient, PBMCs treated with HFn-Cur 2 |
| GSM6171506 |
AD patient, PBMCs treated with HFn-Cur 3 |
| GSM6171507 |
AD patient, PBMCs treated with HFn-Cur 4 |
| GSM6171508 |
Control, PBMCs treated with HFn-Cur 1 |
| GSM6171509 |
Control, PBMCs treated with HFn-Cur 2 |
| GSM6171510 |
Control, PBMCs treated with HFn-Cur 3 |
| GSM6171511 |
Control, PBMCs treated with HFn-Cur 4 |
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| Relations |
| BioProject |
PRJNA839773 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE203408_RAW.tar |
43.4 Mb |
(http)(custom) |
TAR (of RESULTS) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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