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| Status |
Public on Jul 21, 2022 |
| Title |
Prefrontal cortex transcriptome of Arid1b heterozygote mutation mice age of postnatal day 10 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Arid1b is a chromatin remodeler implicated in neurodevelopmental disorders. Arid1b mutant mice with haploinsufficiency (Arid1b HT) displayed persistent excitatory synaptic dysfunction from juvenile to adult stage, decreased synaptic density and transmission. Moreover, they showed autistic-like behaviors in both of early and adult stages, decreased sociability in pup USV calling and adult social interaction, and adult repetitive grooming. To investigate early transcriptomic changes in Arid1b mutant mice, RNAseq analysis of prefrontal cortex from wild-type and Arid1b mutant mice at postnatal day 10 was done. Transcriptomic changes support these electrophysiological and behavioral deficits. Arid1b HT mice at postnatal day 10 showed alterations in genes implicated in synaptic functions and ASD.
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| Overall design |
Prefrontal cortex transcriptome of Arid1b heterozygote mutation mice age of postnatal day 10
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| Contributor(s) |
Kim E, Kim H, Kang H |
| Citation(s) |
36030255 |
| |
| Submission date |
May 18, 2022 |
| Last update date |
Sep 15, 2022 |
| Contact name |
Eunjoon Kim |
| E-mail(s) |
kime@kaist.ac.kr
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| Phone |
82-42-350-2633
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| Organization name |
IBS/KAIST
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| Department |
Center for Synaptic Brain Dysfunctions/Department of Biological Sciences
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| Street address |
Kuseong-dong
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| City |
Daejeon |
| ZIP/Postal code |
305-701 |
| Country |
South Korea |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (10)
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| This SubSeries is part of SuperSeries: |
| GSE203344 |
Brain transcriptome analysis of Arid1b heterozygote mutation and long-lasting effects of early chronic fluoxetine treatment for mutant mice |
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| Relations |
| BioProject |
PRJNA839255 |
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