|
| Status |
Public on May 18, 2022 |
| Title |
Transcriptome analysis of hepatocellular carcinoma and adjacent non-tumor liver tissues [I] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Integrin alpha 6 (ITGA6) forms integrin receptors with either integrin β1 (ITGB1) or integrin beta 4 (ITGB4). To study its expression and regulatory functions in hepatocellular carcinoma (HCC) progression, whole transcriptome RNA sequencing in paired HCC tumor and adjacent non-tumor liver tissue samples from ten local Hispanic patients was performed. The average expression of ITGA6 was found increased by over 3.5-fold in HCC tumor tissues in comparison with their adjacent non-tumor tissues. The study indicates integrin alpha6-beta4 complex as a potential therapeutic target for treating patients in HCC.
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| |
|
| Overall design |
10 tumor-normal pairs of HCC samples were profiled using high-throughput RNA sequencing techniques and their relative gene expression levels were compared.
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| Contributor(s) |
Sun L, Cigarroa F, Bouamar H, Chen Y, Lai Z |
| Citation(s) |
35657344, 38830975 |
| |
| Submission date |
May 12, 2022 |
| Last update date |
Sep 25, 2024 |
| Contact name |
Yidong Chen |
| E-mail(s) |
cheny8@uthscsa.edu
|
| Phone |
2105629163
|
| Organization name |
UT Health Science Center at San Antonio
|
| Department |
Population Health Sciences
|
| Street address |
8403 Floyd Curl Drive, MSC 7784
|
| City |
San Antonio |
| State/province |
Texas |
| ZIP/Postal code |
78229 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
|
| Samples (20)
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| This SubSeries is part of SuperSeries: |
| GSE233422 |
Transcriptome analysis of hepatocellular carcinoma and adacent non-tumor liver tissues |
|
| Relations |
| BioProject |
PRJNA837535 |
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