NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE202643 Query DataSets for GSE202643
Status Public on May 24, 2023
Title MitoKO: A library of base editors for precise ablation of all protein-coding genes in the mouse mitochondrial genome
Organism Mus musculus
Experiment type Other
Summary We design and apply a highly optimized library of double-stranded DNA deaminase (DddA)-derived cytosine base editors (DdCBEs) - MitoKO - to precisely ablate every mtDNA protein coding gene in the mouse mitochondrial genome
 
Overall design Base editing of citosine to timine to introduce premature STOP codons in protein-encoding genes of the mouse mtDNA
 
Contributor(s) Silva-Pinheiro P, Van Haute L
Citation(s) 36470976
Submission date May 10, 2022
Last update date May 24, 2023
Contact name Lindsey Van Haute
Organization name University of Cambridge
Department MRC Mitochondrial Biology Unit
Street address Hills Road
City Cambridge
ZIP/Postal code CB2 0XY
Country United Kingdom
 
Platforms (2)
GPL16417 Illumina MiSeq (Mus musculus)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (205)
GSM6127510 mtDNAwide_WT_T2A_Stable_without HHR_pairID_ [5E1]
GSM6127511 mtDNAwide_Nd3_T2A_Stable_without HHR_pairID_32 [5E2]
GSM6127512 mtDNAwide_Cytb_T2A_Stable_without HHR_pairID_42 [5E3]
Relations
BioProject PRJNA836873

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE202643_mitoKO.xlsx 40.2 Kb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record
| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap