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| Status |
Public on Apr 24, 2022 |
| Title |
Copy number variations may contribute to congenital heart defect risk greatly by disrupting long noncoding RNAs |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We identified lncRNAs locating in CNV locus which were coexpressed with multiple congenital heart defect associated genes. To validate our findings, we performed overexpression and knockdown experiments to characterize the trascriptomic profiles regulated by HSALNG0104472.
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| Overall design |
Paired RNA-seq of lncRNA HSALNG0104472 knockdown cardiomyocytes (AC16), HSALNG0104472 overexpression cardiomyocytes, control cardiomyocytes for overexpression of HSALNG0104472 and control cardiomyocytes for knockdown of HSALNG0104472. Three biological replicates were obtained for each sample.
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| Web link |
https://www.nature.com/articles/s42003-023-04565-z
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| |
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| Contributor(s) |
Lu Y, Fang Q, Wang B |
| Citation(s) |
36806749 |
| |
| Submission date |
Apr 19, 2022 |
| Last update date |
Mar 06, 2023 |
| Contact name |
Yibo Lu |
| E-mail(s) |
wave8013@sjtu.edu.cn
|
| Phone |
18916600183
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| Organization name |
Shanghai Jiao Tong University
|
| Department |
Shanghai Children's Medical Center
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| Street address |
No.1678, Dongfang Road, Shanghai
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| City |
Shanghai |
| ZIP/Postal code |
200025 |
| Country |
China |
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| Platforms (1) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA828187 |
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