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| Status |
Public on Aug 08, 2023 |
| Title |
Comparing the cerebellar transcriptome of Sacs KO versus WT mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) is caused by mutations in SACS gene encoding sacsin. ARSACS patients and mouse models display early degeneration of cerebellum in agreement with high sacsin expression in this organ. We performed unbiased transcriptomic of cerebella from Sacs KO mice versus controls to dissect the mechanisms underlying cerebellar degeneration in ARSACS.
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| Overall design |
Cerebella derived from 5 Sacs KO versus 5 WT littermates at 5 months of age.
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| Contributor(s) |
Maltecca F, Del Bondio A |
| Citation(s) |
37159335 |
| |
| Submission date |
Apr 15, 2022 |
| Last update date |
Aug 08, 2023 |
| Contact name |
Francesca Maltecca |
| E-mail(s) |
maltecca.francesca@hsr.it
|
| Phone |
+390226439116
|
| Organization name |
Ospedale San Raffaele
|
| Department |
Division of Neuroscience
|
| Lab |
Mitochondrial Dysfunctions in Neurodegeneration
|
| Street address |
Via Olgettina, 58
|
| City |
Milan |
| State/province |
Milan |
| ZIP/Postal code |
20132 |
| Country |
Italy |
| |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA827122 |
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