|
| Status |
Public on May 31, 2022 |
| Title |
Investigation of bone marrow microenvironment-induced drug resistance in acute lymphoblastic leukemia (ALL) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Bulk RNA-seq of B-ALL cells cocultured with bone marrow-mesenchymal stem cells (BM-MSC) identified that B-ALL acquire epithelial-mesenchymal transition (EMT) properties by interacting with primary bone marrow-mesenchymal stem cells (BM-MSC) and scRNA-seq dissected the hybrid cluster of adherent B-ALL (Adh B-ALL) harboring B-ALL and BM-MSC features induced by EMT program
|
| |
|
| Overall design |
Integrative analysis of transcriptome in ALL cells interacting with BM-MSC using bulk RNA-seq and single cell RNA-seq
|
| |
|
| Contributor(s) |
Park CS, Yoshihara H, Gao Q, Qu C, Mullighan C |
| Citation(s) |
37453060 |
| |
| Submission date |
Apr 03, 2022 |
| Last update date |
Oct 03, 2023 |
| Contact name |
QINGSONG GAO |
| E-mail(s) |
gaoqs313@gmail.com
|
| Organization name |
ST JUDE CHILDREN'S RESEARCH HOSPITAL
|
| Street address |
262 DANNY THOMAS PLACE
|
| City |
MEMPHIS |
| State/province |
Tennessee |
| ZIP/Postal code |
38105 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (47)
|
|
| Relations |
| BioProject |
PRJNA822779 |
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