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| Status |
Public on Apr 05, 2022 |
| Title |
Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Th17 cells are involved in controlling systemic S. aureus infections especially in the kidney and T-bet expression during transdifferentiation by Th17 cells is required for bacterial clearance.
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| Overall design |
Single cell sequencing of 6-8 week Il17aCre x R26eYFP and Il17aCre x R26eYFP x Tbx21-flox mice
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| Web link |
https://pubmed.ncbi.nlm.nih.gov/35446923/
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| Contributor(s) |
Bartsch P, Kilian C, Hellmig M, Paust H, Borchers A, Sivayoganathan A, Enk L, Zhao Y, Shaik N, Büttner H, Wong MN, Puelles VG, Wiech T, Flavell R, Huber TB, Turner J, Bonn S, Huber S, Gagliani N, Mittrücker H, Rohde H, Panzer U, Krebs CF |
| Citation(s) |
35446923 |
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| Submission date |
Mar 31, 2022 |
| Last update date |
Jul 05, 2022 |
| Contact name |
Yu Zhao |
| E-mail(s) |
yu.zhao@zmnh.uni-hamburg.de
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| Organization name |
University Medical Center Hamburg-Eppendorf
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| Department |
Institute of Medical Systems Biology
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| Street address |
Falkenried 94
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| City |
Hamburg |
| ZIP/Postal code |
20251 |
| Country |
Germany |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA821838 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE199857_RAW.tar |
75.0 Mb |
(http)(custom) |
TAR (of MTX, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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