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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Nov 04, 2022 |
| Title |
IL-6 signaling in CD8 T cells promotes resistance to anti-PD-L1 immunotherapy |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
This SuperSeries is composed of the SubSeries listed below.
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| Overall design |
Refer to individual Series
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| Citation(s) |
36599350 |
| |
| Submission date |
Mar 21, 2022 |
| Last update date |
Feb 07, 2023 |
| Contact name |
Kobe Yuen |
| E-mail(s) |
yuenc4@gene.com
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| Phone |
6504678070
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| Organization name |
Genentech
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| Department |
Oncology Biomarker Development
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| Street address |
1 DNA WAY
|
| City |
SOUTH SAN FRANCISCO |
| State/province |
California |
| ZIP/Postal code |
94080 |
| Country |
USA |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (65)
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| GSM4567408 |
spleen, IL6_1 |
| GSM4567409 |
spleen, IL6_2 |
| GSM4567410 |
spleen, IL6_3 |
| GSM4567411 |
spleen, hyper-IL6_1 |
| GSM4567412 |
spleen, hyper-IL6_2 |
| GSM4567413 |
spleen, hyper-IL6_3 |
| GSM4567414 |
spleen, IgG_1 |
| GSM4567415 |
spleen, IgG_2 |
| GSM4567416 |
spleen, IgG_3 |
| GSM4567417 |
spleen, anti-IL6R_1 |
| GSM4567418 |
spleen, anti-IL6R_2 |
| GSM4567419 |
spleen, anti-IL6R_3 |
| GSM5962897 |
day 2, IgG_replicate 1 |
| GSM5962898 |
day 2, IgG_replicate 2 |
| GSM5962899 |
day 2, IgG_replicate 3 |
| GSM5962900 |
day 2, anti-IL6R_replicate 1 |
| GSM5962901 |
day 2, anti-IL6R_replicate 2 |
| GSM5962902 |
day 2, anti-IL6R_replicate 3 |
| GSM5962903 |
day 2, IL6_replicate 1 |
| GSM5962904 |
day 2, IL6_replicate 2 |
| GSM5962905 |
day 2, IL6_replicate 3 |
| GSM5962906 |
day 7, IgG_replicate 1 |
| GSM5962907 |
day 7, IgG_replicate 2 |
| GSM5962908 |
day 7, IgG_replicate 3 |
| GSM5962909 |
day 7, anti-IL6R_replicate 1 |
| GSM5962910 |
day 7, anti-IL6R_replicate 2 |
| GSM5962911 |
day 7, anti-IL6R_replicate 3 |
| GSM5962912 |
day 7, IL6_replicate 1 |
| GSM5962913 |
day 7, IL6_replicate 2 |
| GSM5962914 |
day 7, IL6_replicate 3 |
| GSM5962915 |
untreated_replicate_1 [SAM24371013] |
| GSM5962916 |
untreated_replicate_2 [SAM24371014] |
| GSM5962917 |
untreated_replicate_3 [SAM24371015] |
| GSM5962918 |
IL6_replicate 1 [SAM24371016] |
| GSM5962919 |
IL6_replicate 2 [SAM24371017] |
| GSM5962920 |
IL6_replicate 3 [SAM24371018] |
| GSM5962921 |
anti-CD3/28+ IL2_replicate 1 [SAM24371031] |
| GSM5962922 |
anti-CD3/28+ IL2_replicate 2 [SAM24371032] |
| GSM5962923 |
anti-CD3/28+ IL2_replicate 3 [SAM24371033] |
| GSM5962924 |
anti-CD3/28+ IL2+IL6_replicate 1 [SAM24371034] |
| GSM5962925 |
anti-CD3/28+ IL2+IL6_replicate 2 [SAM24371035] |
| GSM5962926 |
anti-CD3/28+ IL2+IL6_replicate 3 [SAM24371036] |
| GSM5963059 |
WT_CD8_isotype_1 |
| GSM5963060 |
WT_CD8_isotype_2 |
| GSM5963061 |
WT_CD8_isotype_3 |
| GSM5963062 |
WT_CD8_isotype_4 |
| GSM5963063 |
WT_CD8_isotype_5 |
| GSM5963064 |
WT_CD8_anti-PDL1_1 |
| GSM5963065 |
WT_CD8_anti-PDL1_2 |
| GSM5963066 |
WT_CD8_anti-PDL1_3 |
| GSM5963067 |
WT_CD8_anti-PDL1_4 |
| GSM5963068 |
WT_CD8_anti-PDL1_5 |
| GSM5963069 |
Il6r.ko_CD8_isotype_1 |
| GSM5963070 |
Il6r.ko_CD8_isotype_2 |
| GSM5963071 |
Il6r.ko_CD8_isotype_3 |
| GSM5963072 |
Il6r.ko_CD8_isotype_4 |
| GSM5963073 |
Il6r.ko_CD8_isotype_5 |
| GSM5963074 |
Il6r.ko_CD8_anti-PDL1_1 |
| GSM5963075 |
Il6r.ko_CD8_anti-PDL1_2 |
| GSM5963076 |
Il6r.ko_CD8_anti-PDL1_3 |
| GSM5963077 |
Il6r.ko_CD8_anti-PDL1_4 |
| GSM5963078 |
Il6r.ko_CD8_anti-PDL1_5 |
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| This SuperSeries is composed of the following SubSeries:
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| GSE151157 |
Effect of IL-6 on antigen-specific CD8+ T cell activation in vitro |
| GSE199044 |
Transcriptional effects of IL-6 on peptide-stimulated OT-I CD8 T cells after 2 or 7 days |
| GSE199045 |
Acute transcriptional effects of IL-6 on murine naive CD8 T cells |
| GSE199047 |
Transcriptional profiling of IL6R-deficient CD8 T cells isolated from subcutaneous MC38 tumors treated with anti-PD-L1 therapy |
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| Relations |
| BioProject |
PRJNA818179 |
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