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| Status |
Public on Mar 20, 2022 |
| Title |
Differentially expressed lncRNAs profile between ischemic stroke patients and non-stroke patients in South China |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
To evaluate lncRNA expression and changes in whole blood samples of patients during the acute cerebral ischemia phase, we have employed whole genome microarray expression profiling as a discovery platform to identify dysregulated genes to put forth predicted connections and functions of the differentially expressed lncRNAs.There were 1123 differentially expressed lncRNAs (Fold change ≥2.0, p<0.05) between stroke patients and the control group. Among these, 371 lncRNAs were upregulated, and 752 lncRNAs were downregulated. Expression of nine lncRNAs (ENST00000452599, ENST00000527450, ENST00000608826, T013651, T029143, T131416, T294865, ENST00000530525 and T058035) from this signature was quantified in the same RNA samples by real-time PCR, confirming our gene chip performance.
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| Overall design |
For five stroke patients, it was performed after symptom onset, with times varying from a few hours to two weeks. For five control samples, this time point was recorded as zero.
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| Contributor(s) |
Jiang W, Cheng X |
| Citation(s) |
35754821 |
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| Submission date |
Mar 15, 2022 |
| Last update date |
Jul 01, 2022 |
| Contact name |
Wen Jiang |
| E-mail(s) |
jw15228948069@gmail.com
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| Phone |
15228948069
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| Organization name |
Guangzhou University of Traditional Chinese Medicine
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| Department |
Department of Second Institute of Clinical Medicine
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| Street address |
111 Dade Road
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| City |
Guangzhou |
| State/province |
Guangdong |
| ZIP/Postal code |
510120 |
| Country |
China |
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| Platforms (1) |
| GPL21827 |
Agilent-079487 Arraystar Human LncRNA microarray V4 (Probe Name version) |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA816528 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE198710_RAW.tar |
27.3 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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