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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Feb 01, 2023 |
| Title |
Patient-derived organoid fibroblast co-cultures closely mimic tumor cell heterogeneity of colorectal cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Here we compare RNA expression profiles of colorectal cancer organoids grown in four different conditions, namely standard organoids medium, minimal medium without growth factors or with normal or cancer associated fibroblasts. We found majorly different expression profiles between conditions and more heterogeneous tumor cell population in organoids grown with fibroblasts.
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| Overall design |
Evaluation of RNA expression changed caused by co-culturing of tumor cells and fibroblasts
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| Contributor(s) |
Atanasova VS, de Jesus Cardona C, Hejret V, Binder C, Kabiljo J, Tiefenbacher A, Tran L, Clement J, Müllauer L, Tichy B, Woeran K, Neudert B, Hengstschläger M, Mitterhauser M, Bergmann M, Schweikert G, Dolznig H, Egger G, Hartl M |
| Citation(s) |
36868311 |
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| Submission date |
Mar 15, 2022 |
| Last update date |
May 12, 2023 |
| Contact name |
Vaclav Hejret |
| Organization name |
Masaryk University
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| Street address |
Kamenice 5
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| City |
Brno |
| ZIP/Postal code |
62500 |
| Country |
Czech Republic |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (72)
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| Relations |
| BioProject |
PRJNA816490 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE198697_RAW.tar |
206.5 Mb |
(http)(custom) |
TAR (of TSV) |
| GSE198697_rsem_gene_counts.tsv.gz |
6.1 Mb |
(ftp)(http) |
TSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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