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| Status |
Public on Nov 05, 2022 |
| Title |
Activation of RXRα reprograms chromatin accessibility to protect against acute kidney injury [RNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Purpose: To explore whether the differences in chromatin openness correlate with distinct gene expression in PTCs of MI and SI
Methods: Proximal tubules were isolated for RNA-seq
Results: Using an optimized data analysis workflow, we mapped reads to the mouse genome (mm10). Approximately 2%-13% of the transcripts showed differential expression within the different groups, with a fold change >= 1.5 and p value <0.05.
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| Overall design |
RNA-sequencing of different conditions: Sham and bilateral ischemia-reperfusion injury (bIRI) mice with or without bexoratene
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| Contributor(s) |
Cao X, Chen Y |
| Citation(s) |
36443310 |
| |
| Submission date |
Mar 02, 2022 |
| Last update date |
Dec 15, 2022 |
| Contact name |
Xinyi Cao |
| E-mail(s) |
cxyldd@tmu.edu.cn
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| Organization name |
Tianjin Medical University
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| Street address |
Qi Xiangtai Road, HePing District, Tianjin, P.R. China
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| City |
Tianjin |
| State/province |
State... |
| ZIP/Postal code |
300070 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (24)
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| This SubSeries is part of SuperSeries: |
| GSE197815 |
Activation of RXRα reprograms chromatin accessibility to protect against acute kidney injury. |
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| Relations |
| BioProject |
PRJNA812331 |
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