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Series GSE196444 Query DataSets for GSE196444
Status Public on Jan 25, 2024
Title Transcriptomic changes in embryonic hearts from Dp3Tyb and Ts1Rhr mouse models of Down Syndrome
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We performed bulk RNAseq on whole hearts from E13.5 Dp3Tyb embryos and from wild-type littermates, as well as hearts from E13.5 Ts1Rhr embryos and wild-type littermates. Analysis showed the expected increased expression of the Hsa21-orthologous genes on Mmu16 that are present in 3 copies. Gene set enrichment analysis identified pathways that are altered in Dp3Tyb and Ts1Rhr hearts.
Overall design RNAseq on 5 E13.5 Dp3Tyb embryonic hearts and 5 wild-type littermate embryonic hearts, and on 5 E13.5 Ts1Rhr embryonic hearts and 5 wild-type littermate embryonic hearts.
Contributor(s) Lana-Elola E, Llorian M, Tybulewicz V
Citation(s) 38266108
Submission date Feb 09, 2022
Last update date Apr 25, 2024
Contact name Victor Tybulewicz
Organization name Francis Crick Institute
Street address 1 Midland Road
City London
ZIP/Postal code NW1 1AT
Country United Kingdom
Platforms (1)
GPL21103 Illumina HiSeq 4000 (Mus musculus)
Samples (20)
GSM5884325 LAN233A1
GSM5884326 LAN233A2
GSM5884327 LAN233A3
This SubSeries is part of SuperSeries:
GSE196447 Down Syndrome
BioProject PRJNA804914

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE196444_Normalized_counts.txt.gz 2.7 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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