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| Status |
Public on Sep 21, 2022 |
| Title |
RNA Sequencing of melanoma cell line (WM983B) upon Fbxo4 knock-down |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Fbxo4 is a member of Skip1-Cullin1-F-box protein E3 ubiquitin ligase complex that controls RNA biding proteins. We report that loss of Fbxo4 in melanoma contribute to altered gene expression leading to dysregulation pathways reponsible for cell-cell interaction, cell anocharege, invasion and motility.
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| |
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| Overall design |
WM983B melanoma cell line were infected with empty lentiviral vector (control) or lentivirus encoding anti-Fbxo4 shRNA.
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| |
|
| Contributor(s) |
A Diehl J, Mucha B |
| Citation(s) |
36329064 |
| |
| Submission date |
Feb 08, 2022 |
| Last update date |
Dec 22, 2022 |
| Contact name |
J Alan Diehl |
| E-mail(s) |
jad283@case.edu
|
| Phone |
2163680268
|
| Organization name |
Case Western Reserve University
|
| Department |
Department of Biochemistry
|
| Lab |
Deihl Lab
|
| Street address |
2109 Adelbert Rd. SOM Wood/W402
|
| City |
Cleveland |
| State/province |
Ohio |
| ZIP/Postal code |
44106 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA804586 |
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