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| Status |
Public on Sep 01, 2022 |
| Title |
Menopausal Transition: Prospective Study of Estrogen Status, Circulating MicroRNAs, and Biomarkers of Bone Metabolism |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We carried out Massive Parallel Sequencing (MPS) to reveal circulating miRNA profiles of 44 patients before and after oophorectomy, as well as in oophorectomized women on estrogen therapy. The sequencing platform identified 1305 miRNA species, out of which 439 miRNAs were present with the base mean, computed by DESeq2, more than 10. We identified 17 miRNAs, which were different in sera with sufficient and low estrogen levels.
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| |
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| Overall design |
miRNA profiling of 44 sera from women before and after oophorectomy, as well as in oophorectomized.
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| |
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| Contributor(s) |
Baloun J, Stepan JJ |
| Citation(s) |
35634507 |
| |
| Submission date |
Jan 20, 2022 |
| Last update date |
Dec 01, 2022 |
| Contact name |
Jiri Baloun |
| E-mail(s) |
jubarowe@gmail.com
|
| Organization name |
Institute of Rheumatology
|
| Department |
Department of experimental rheumatology
|
| Street address |
Na Slupi 450/4
|
| City |
Prague |
| ZIP/Postal code |
12800 |
| Country |
Czech Republic |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (44)
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| Relations |
| BioProject |
PRJNA799016 |
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