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| Status |
Public on Jun 09, 2022 |
| Title |
Epigenome-wide profiling uncovers novel pathway networks in human pulmonary arterial hypertension [pul31] |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Pulmonary arterial hypertension (PAH) is a progressive pulmonary vascular disease that culminates in right heart failure. Vascular pathology in PH is characterized by pulmonary vasoconstriction and progressive vascular remodeling processes that affects all layers of the vascular wall (intima, media and adventitia). Our objective was to profile and analyze the differential gene expression signatures between the cells isolated from normal and idiopathic PAH patients. We generated vascular cell-specific transcriptome profiles from the adventitial fibroblasts (PAAF) isolated ex vivo from the dissected human pulmonary arteries of normal donor and PAH lungs using paired-end RNA-sequencing.
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| Overall design |
Transcriptome profiling of lung tissue from healthy control or monocrotaline-induced PAH animals treated with vehicle or compound SGC-CBP30.
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| Contributor(s) |
Chelladurai P, Kuenne C, Bourgeois A, Günther S, Valasarajan C, Cherian AV, Rottier RJ, Romanet C, Weigert A, Boucherat O, Eichstaedt CA, Ruppert C, Guenther A, Braun T, Savai R, Looso M, Seeger W, Bauer UM, Bonnet S, Pullamsetti SS |
| Citation(s) |
35675437 |
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| Submission date |
Jan 20, 2022 |
| Last update date |
Jun 10, 2022 |
| Contact name |
Carsten Kuenne |
| E-mail(s) |
Carsten.Kuenne@mpi-bn.mpg.de
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| Organization name |
Max Planck Institute for Heart and Lung Research
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| Department |
Bioinformatics
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| Street address |
Ludwigstrasse 43
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| City |
Bad Nauheim |
| ZIP/Postal code |
61231 |
| Country |
Germany |
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| Platforms (1) |
| GPL20084 |
Illumina NextSeq 500 (Rattus norvegicus) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA798969 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE194067_pul31_rnaseq.txt.gz |
822.4 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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