|
| Status |
Public on Jan 24, 2022 |
| Title |
Astrocyte immunosenescence in IL-10 and cholesterol signaling in the aged brain impairs microglial regulation following peripheral immune activation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The purpose of this study was to determine the cell-, age-, and time-specific transcriptional profiles of cells within the brain after peripheral immune challenge with lipopolysaccharide.
|
| |
|
| Overall design |
Hippocampal transcriptional profiles of adult and aged BALB/c mice with i.p. saline or 4h or 24h after i.p. LPS.
|
| Web link |
https://onlinelibrary.wiley.com/doi/10.1002/glia.24147
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| |
|
| Contributor(s) |
O'Neil SM, Hans EE, Jiang S, Wangler LM, Godbout JP |
| Citation(s) |
35061297 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 AG051902 |
Consequences of Age-Related Impairments in the Dynamic Regulation of Active Microglia by Astrocytes |
OHIO STATE UNIVERSITY |
Jonathan P Godbout |
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| |
| Submission date |
Jan 13, 2022 |
| Last update date |
Oct 10, 2024 |
| Contact name |
Shane Mitchell O'Neil |
| Organization name |
Duke University
|
| Department |
Neuroscience
|
| Lab |
Filiano Lab
|
| Street address |
701 W Main St
|
| City |
Durham |
| State/province |
NC |
| ZIP/Postal code |
27701 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA796965 |
| SRA |
SRP354892 |
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