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Series GSE19322 Query DataSets for GSE19322
Status Public on May 01, 2010
Title Expression data from C57BL/6J and MRL/MpJ hearts following acute myocardial infarction
Organism Mus musculus
Experiment type Expression profiling by array
Summary The Murphy Roth Large (MRL) mouse, a strain capable of regenerating right ventricular myocardium, has a high post-myocardial infarction (MI) survival rate compared with C57BL6/J (C57) mice. The biological processes responsible for this survival advantage are unknown.
We compared acute post-MI gene expression in C57 and MRL hearts using microarrays and identified promising candidate biological processes underlying increased survival in the MRL.
 
Overall design Hearts from both strains were excised at different time points before or after MI for RNA extraction and hybridization to MOE430A arrays. Baseline hearts were excised from healthy mice that had not undergone the MI procedure (day 0). Infarct tissue in this case means tissue taken from the anterior-apical region that would be the infarct region in a post-MI heart. Non-infarct covers the remainder of the LV. Post-MI hearts were excised either 1 or 5 days after MI. We had successful hybridizations for 3 replicates each of C57 day 0 infarct and non-infarct tissue (6 arrays), 4 MRL day 0 infarct and non-infarct tissue (8 arrays), 4 C57 day 1 infarct and non-infarct tissue (8 arrays), 4 MRL day 1 infarct and non-infarct tissue (8 arrays), 4 C57 day 5 infarct and non-infarct tissue (8 arrays), and 4 MRL day 5 infarct and non-infarct tissue (8 arrays).
 
Contributor(s) Hunt DL, Campbell PH, Zambon AC, Vranizan K, Evans SM, Kuo H, Yamaguchi KD, Omens JH, McCulloch AD
Citation(s) 21967898
Submission date Dec 04, 2009
Last update date Jan 08, 2019
Contact name Darlene L Hunt
Organization name UC San Diego
Department Bioengineering
Lab Cardiac Mechanics Research Group
Street address 9500 Gilman Drive #0412
City La Jolla
State/province CA
ZIP/Postal code 92093-0412
Country USA
 
Platforms (1)
GPL339 [MOE430A] Affymetrix Mouse Expression 430A Array
Samples (46)
GSM480106 C57 infarct at day 1, biological rep 1
GSM480107 MRL infarct at baseline (day 0), biological rep 1
GSM480108 MRL non-infarct at baseline, biological rep 1
Relations
BioProject PRJNA120865

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE19322_RAW.tar 100.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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