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| Status |
Public on Apr 05, 2022 |
| Title |
RNA-Seq of intraductal breast cancer PDX hormonally treated |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Using a large variety of methods we demostrate that PGR can be a driver of tumor proliferation even in absence of high E2. In this specific experiment we treat breast cancer cells intraductally xenografted into the ductal tree of a mouse mammary gland, with estrogen (E2), progesterone (P4) and the combination of the two (E2+P4).
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| Overall design |
PDX cells were grown intraductally for around 2 months then hormone-releasing pellets were implanted subcutaneously where they were left for 60 days.
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| Contributor(s) |
Scabia V, Ambrosini G |
| Citation(s) |
35668111 |
| |
| Submission date |
Dec 30, 2021 |
| Last update date |
Jun 23, 2022 |
| Contact name |
Giovanna Ambrosini |
| E-mail(s) |
giovanna.ambrosini@epfl.ch
|
| Organization name |
EPFL
|
| Street address |
Station 19
|
| City |
Lausanne |
| ZIP/Postal code |
1015 |
| Country |
Switzerland |
| |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (76)
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| Relations |
| BioProject |
PRJNA793250 |
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