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| Status |
Public on Sep 30, 2022 |
| Title |
Vitamin C promotes anti-leukemia of DZNep in Acute Myeloid Leukemia |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The epigenetic treatment by 3-Deazaneplanocin A (DZNep), a histone methyltransferase inhibitor, shows great potential against acute myeloid leukemia (AML). However, the variant sensitivity and incomplete response to DZNep are commonly observed. We reveal that vitamin C (Vc) dramatically promotes DZNep response against leukemic cells in different cell lines and primary AML samples. To examine the molecular determinants underlying Vc enhanced anti-leukemia effect of DZNep, we conducted a genome-wide RNA sequencing and a gene ontology (GO) enrichment analysis of differentially expressed mRNAs in each group was performed.
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| Overall design |
The experiment was divided into four groups: PBS treatment group, VC treatment group, DZNep treatment group, VC and DZNep treatment group.
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| Contributor(s) |
Long B, Shan Y, Wang T, Pan G |
| Citation missing |
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| |
| Submission date |
Dec 26, 2021 |
| Last update date |
Sep 30, 2022 |
| Contact name |
Bing Long |
| E-mail(s) |
longb3@mail.sysu.edu.cn
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| Phone |
+86 13480200865
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| Organization name |
The Third Affiliated Hospital, Sun Yat-sen University
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| Department |
Department of Hematology
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| Street address |
No. 600 Tianhe Road
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| City |
Guangzhou |
| ZIP/Postal code |
510630 |
| Country |
China |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA792424 |
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