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| Status |
Public on Apr 06, 2022 |
| Title |
Integrated Analysis of lncRNA and mRNA Expression Profiles Indicates Age-related Changes in Meniscus |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
Non-coding RNA profiling by high throughput sequencing
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| Summary |
Little has been known about the role of long non-coding RNA (lncRNA) involves in meniscus degradation with aging.In order to investigate the molecular mechanisms of age-related meniscal degeneration and further explore potential biologic therapeutic targets, we performed microarray analysis of meniscus to determine lncRNAs and mRNAs expression profiles in young and aging adults. Then, we carried out bioinformatics analysis of differentially expressed molecules to identify key molecules and functional pathways in the aged meniscus tissues.
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| Overall design |
The torn segment of the injured meniscus was resected from eight patients who underwent arthroscopic meniscus repair surgery with no significant cartilage degeneration, osteoarthritis, rheumatoid arthritis and other metabolic diseases. For the current study, these tissues were divided into two categories based on patients’ age: young group (n = 4, 20–25 years old) and aging group (n = 4, 50-55 years old).
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| Contributor(s) |
Ai L, Du Z, Chen Y, Xia P, Zhang J, Jiang D |
| Citation(s) |
35359458 |
| |
| Submission date |
Dec 17, 2021 |
| Last update date |
Apr 07, 2022 |
| Contact name |
Jinghua Yang |
| E-mail(s) |
yangjh@xy-data.net
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| Organization name |
Beijing Zhiyun data technology co. LTD
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| Street address |
32 North Third Ring Road West, Haidian District, Beijing
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| City |
Beijing |
| ZIP/Postal code |
100098 |
| Country |
China |
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| Platforms (1) |
| GPL26963 |
Agilent-085982 Arraystar human lncRNA V5 microarray |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA789899 |
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