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| Status |
Public on Nov 25, 2021 |
| Title |
Transcriptomic profile of liver fibrosis in mice induced by CCl4 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
This study is aimed to investigate the underlying mechanisms of didymin on anti-hepatic fibrosis. In brief, mice were randomly devided into three groups,including normal, CCl4 and didymin groups. Except the normal group, mice were intra-peritonelly administrated with 20% CCl4 for 10 weeks to induce liver fibrosis; after modeling successfully, mice in didymin group were subsequently intragastrically administrated with didymin for 6 weeks. Finally, the transcriptomic analysis was performed to acquire the differently expressed genes amog the three groups, trying to figure out the potential targets, which regulated by didymin.
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| Overall design |
Mice were randomly devided into three groups, including normal group, CCl4 group (20% CCl4 for 10 weeks, ip) and didymin group (20% CCl4 for 10 weeks, ip + didymin for 6 weeks, ig).
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| Contributor(s) |
Li Y, Xiong Y, Fang b, Li C |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Nov 23, 2021 |
| Last update date |
Nov 27, 2021 |
| Contact name |
xing lin |
| Organization name |
Guangxi medical university
|
| Street address |
Shuangyong Road
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| City |
Nanning |
| ZIP/Postal code |
530001 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA782960 |
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