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| Status |
Public on Dec 05, 2021 |
| Title |
Expression data from intestinal mucosa of patients with Crohn disease |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We used microarrays to detail the global signature of gene expression underlying endoscopic recurrence of CD and identified distinct gene signature predicting postoperative recurrence.
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| Overall design |
Ileal samples from Crohn's disease patients and healthy samples from non-inflammatory controls were collected for RNA extraction and hybridization on Affymetrix microarrays. Inclusion criteria were age >18 years, ileal or ileocolonic CD and indication of CDârelated intestinal surgery. Endoscopic recurrence was defined by the presence of any ulcerated lesions at the anastomosis and/or on the neo-terminal ileum (Rutgeerts score > i0). Five hundred and twenty samples (520) were collected from the inflamed ileum (M0I) and the ileal margin (M0M) at time of surgery, and during post-operative endoscopy six month later (M6). We also collected 25 ileal non-IBD control biopsies (Ctrl) from patients who underwent ileocecal resection for colonic tumour with a healthy ileum.
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| Contributor(s) |
Marjolaine N, Matthieu A |
| Citation(s) |
35143619 |
| |
| Submission date |
Oct 26, 2021 |
| Last update date |
Mar 08, 2022 |
| Contact name |
Marjolaine Ngollo |
| E-mail(s) |
nmarjolaine@yahoo.fr
|
| Phone |
+33760872549
|
| Organization name |
INSERM
|
| Department |
Gastroenterology
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| Lab |
Intestinal Immunity in Inflammation and Cancer
|
| Street address |
1 avenue Claude Vellefaux
|
| City |
Paris |
| ZIP/Postal code |
75010 |
| Country |
France |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (489)
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| Relations |
| BioProject |
PRJNA774662 |
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