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Status |
Public on Oct 23, 2009 |
Title |
Radical prostatectomy specimens with and without TMPRSS2:ERG fusion from 139 patients with prostate in a Toronto cohort |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
Prostate tumors with the gene fusion TMPRSS2:ERG have been reported to have a significantly higher risk of recurrence compared with tumors lacking the fusion. Tumors from 139 patients who underwent radical prostatectomy were analyzed for the expression of 502 cancer-related genes to identify genes differentially regulated in TMPRSS2:ERG fusion tumors as well as identify biomarkers of biochemical recurrence.
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Overall design |
139 prostate fresh-frozen tumors from radical prostatectomy surgery where profiled on the Illumina Human Cancer DASL Panel. 69 tumors were positive for the gene fusion TMPRSS2:ERG while 70 where not. 33 of the 139 patients experienced biochemical recurrence. Data was analyzed for differential genes in TMPRSS2:ERG fusion positive tumors as well as clinical and molecular biomarkers of recurrence.
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Contributor(s) |
Barwick BG, Seth A, Leyland-Jones BR, Abramovitz M |
Citation(s) |
20068566 |
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Submission date |
Oct 20, 2009 |
Last update date |
Mar 21, 2012 |
Contact name |
Benjamin G Barwick |
E-mail(s) |
benjamin.barwick@emory.edu
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Phone |
(404) 285-2964
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Organization name |
Emory University
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Department |
Hematology and Medical Oncology
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Lab |
Barwick Lab
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Street address |
1365 Clifton Rd. NE WCI-C 4th Floor Benches 36-37
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City |
Atlanta |
State/province |
GA |
ZIP/Postal code |
30322 |
Country |
USA |
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Platforms (1) |
GPL5858 |
DASL Human Cancer Panel by Gene |
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Samples (139)
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Relations |
BioProject |
PRJNA121595 |