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| Status |
Public on Feb 02, 2022 |
| Title |
Replication of Dengue virus in differentiating K562-megakaryocytes is promoted by virus induced suppression in the accumulation of reactive oxygen species |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Our study reports that over-expression of NRf2 target genes causes reduction in the ROS accumulation in differentiating cells which ultimately enhances Dengue virus replication and we also report the suppression of cell adhesion molecules and platelet specific surface markers in Dengue virus infected K562-megakaryocyte cells.
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| |
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| Overall design |
mRNA profiles of differentiated and undifferentiated K562 cells
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| |
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| Contributor(s) |
Jaskaran K, Yogita R, Vikas S, Neha P, Deepak R, Shrikant K, Niraj K, Sankar B |
| Citation(s) |
35087488 |
| |
| Submission date |
Oct 19, 2021 |
| Last update date |
Feb 02, 2022 |
| Contact name |
Jaskaran Kaur |
| E-mail(s) |
jaskaran.kaur@thsti.res.in
|
| Phone |
8860683867
|
| Organization name |
THSTI
|
| Department |
Infection and immunology
|
| Lab |
Molecular Virology Lab-2
|
| Street address |
NCR Biotech Science cluster Gurugram-Faridabad Expressway
|
| City |
Faridabad |
| State/province |
Haryana |
| ZIP/Postal code |
121001 |
| Country |
India |
| |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (10)
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|
| Relations |
| BioProject |
PRJNA772576 |
| SRA |
SRP342044 |
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