|
| Status |
Public on Jan 07, 2022 |
| Title |
Identification of the Similarities and Differences of Molecular Networks Associated With Fear Memory Formation, Extinction, and Updating in the Amygdala |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
In this study, we systematically observed the expression
of mRNAs, microRNAs (miRNA), long non-coding RNAs (lncRNAs), and circRNAs in
the basolateral amygdala of mice after fear memory formation, extinction, and updating
by whole-transcriptional sequencing, then a variety of inter-group comparison and
bioinformatics analysis were used to find the differential expressed RNAs, enrich the
function of them, and construct the molecular interaction networks. Moreover, competing
endogenous RNA (ceRNA) molecular networks and transcriptional regulatory networks
for the candidate circRNAs were constructed. Through these analyses, we found that
about 10% of molecules were both involved in the fear memory extinction and formation,
but the molecules and their signaling pathways were almost completely different between
fear memory extinction and updating. This study describes a relatively detailed molecular
network for fear memory updating, which might provide some novel directions for further
mechanism research, and help to develop a specific physical method for fear memory
intervention, based on the regulation of these key molecules.
|
| |
|
| Overall design |
Refer to individual Series
|
| |
|
| Citation(s) |
34924954 |
| |
| Submission date |
Oct 13, 2021 |
| Last update date |
Jan 07, 2022 |
| Contact name |
Qi shuai Zhuang |
| E-mail(s) |
zqs305305@aliyun.com
|
| Phone |
18865930712
|
| Organization name |
Shandong First Medical University
|
| Street address |
Shandong First Medical University, Qingdao Road, Huaiyin District
|
| City |
jinan |
| ZIP/Postal code |
250000 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
|
| Samples (24)
|
|
| This SuperSeries is composed of the following SubSeries: |
| GSE185806 |
Identification of the Similarities and Differences of Molecular Networks Associated With Fear Memory Formation, Extinction, and Updating in the Amygdala [circRNA-seq] |
| GSE185807 |
Identification of the Similarities and Differences of Molecular Networks Associated With Fear Memory Formation, Extinction, and Updating in the Amygdala [miRNA-seq] |
|
| Relations |
| BioProject |
PRJNA770902 |
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