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| Status |
Public on Nov 12, 2021 |
| Title |
Investigating the altered brain metastatic transcriptome in breast cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Brain metastatic disease occurs in 10-30% of metastatic breast cancer cases. The incidence of brain metastases is increasing with median overall survival < 2 years for patients. In order to better characterize oncogenic pathway activity pertinent to breast cancer brain metastasis, exome capture RNA sequencing was carried out on patient matched primary breast with brain metastatic tumor samples for 45 cases of breast cancer brain metastasis (N= 90 samples). Here, exome capture RNA sequencing data is deposited as sequencing batch corrected log2 transformed trimmed M of means (TMM) normalized counts per million (CPM) (log2(TMM-CPM +1) gene expression values (n=16,714 protein coding genes; N=90 tumor samples).
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| Overall design |
Exome capture RNA sequencing was carried out on patient matched primary breast with brain metastatic tumor samples for 45 cases of breast cancer brain metastasis (N= 90 samples).
>>> Raw RNA sequencing data for the paired primary and metastatic samples are not published openly in order to protect participant identities, but will be made available upon request and under regulatory compliance via a data usage agreement (DUA). Please contact the corresponding author with data access requests that will be granted once the DUA is signed. <<<
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| Contributor(s) |
Lee AV, Oesttereich S, Couch FJ, Young L, Vareslija D, Cosgrove N |
| Citation(s) |
35082299 |
| |
| Submission date |
Sep 27, 2021 |
| Last update date |
Jul 15, 2022 |
| Contact name |
Leonie Young |
| E-mail(s) |
lyoung@rcsi.com
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| Organization name |
RCSI
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| Department |
Surgery
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| Lab |
Endocrine Oncology Research Group
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| Street address |
31A York Street
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| City |
Dublin |
| State/province |
Dublin |
| ZIP/Postal code |
D02 HX03 |
| Country |
Ireland |
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| Platforms (2) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (90)
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| Relations |
| BioProject |
PRJNA766683 |
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