|
| Status |
Public on Feb 28, 2022 |
| Title |
DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To identify the potential signaling pathway involved in DENR KO cells upon PD-L1 production, we harvested IFNγ-treated control and DENR KO cells for RNA-seq. Bioinformatic analysis of the RNA-seq data showed that 114 genes, including PD-L1, were significantly downregulated in DENR KO cells, and multiple classical signaling pathways, including JAK-STAT, and PD-L1, were enriched.
|
| |
|
| Overall design |
mRNA profiles of DENR KO and control MC38 cells
|
| |
|
| Contributor(s) |
Li H, Chen B |
| Citation(s) |
35440133 |
| |
| Submission date |
Sep 12, 2021 |
| Last update date |
May 05, 2022 |
| Contact name |
Baiwen Chen |
| E-mail(s) |
18111260018@fudan.edu.cn
|
| Organization name |
Shanghai Jiao Tong University School of Medicine
|
| Department |
Shanghai Institute of Immunology
|
| Street address |
south chongqing road
|
| City |
shanghai |
| ZIP/Postal code |
200003 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA762565 |
| SRA |
SRP336736 |
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