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| Status |
Public on May 21, 2010 |
| Title |
Effects of retinoids on estrogen-receptor-positive and -negative breast carcinoma cells: mRNA profiling |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The overall study explores differential sensitivity of estrogen-receptor-positive and -negative breast carcinoma cells to retinoids via gene expression and microRNA profiling in MCF7 and MDA-MB-231 cells.
This Series reports results of transcriptional profiling of breast carcinoma cell lines comparing the effects of retinoic acid treatment (6 and 48 hours) on estrogen-receptor-positive (MCF7) and estrogen-receptor-negative (MDA-MB-231) cells.
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| Overall design |
mRNA profiling: Retinoic-acid-treated (1microM) vs vehicle-treated cells, two time points (6 and 48h), two cell lines (MCF7 and MDA-MB-231). Two biological replicates for each condition, balanced dye design.
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| Contributor(s) |
Terao M, Fratelli M, Tsykin A, Goodall G, Garattini E |
| Citation(s) |
21131358 |
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| Submission date |
Oct 02, 2009 |
| Last update date |
Feb 22, 2018 |
| Contact name |
Maddalena Fratelli |
| E-mail(s) |
maddalena@marionegri.it
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| Phone |
+390239014217
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| Organization name |
"Mario Negri" Institute
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| Lab |
Molecular Biology
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| Street address |
Via La Masa, 19
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| City |
Milano |
| ZIP/Postal code |
I20156 |
| Country |
Italy |
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| Platforms (1) |
| GPL4133 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version) |
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| Samples (8)
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| GSM458610 |
MCF7 cells, retinoic acid effect, time 48h, repl1 |
| GSM458611 |
MCF7 cells, retinoic acid effect, time 48h, repl2 |
| GSM458612 |
MCF7 cells, retinoic acid effect, time 6h, repl1 |
| GSM458613 |
MCF7 cells, retinoic acid effect, time 6h, repl2 |
| GSM458614 |
MDA-MB-231 cells, retinoic acid effect, time 48h, repl1 |
| GSM458615 |
MDA-MB-231 cells, retinoic acid effect, time 48h, repl2 |
| GSM458616 |
MDA-MB-231 cells, retinoic acid effect, time 6h, repl1 |
| GSM458617 |
MDA-MB-231 cells, retinoic acid effect, time 6h, repl2 |
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| This SubSeries is part of SuperSeries: |
| GSE18693 |
Effects of retinoids on estrogen-receptor-positive and -negative breast carcinoma cells: mRNA and miRNA profiling |
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| Relations |
| BioProject |
PRJNA123773 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE18390_RAW.tar |
111.0 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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