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| Status |
Public on Sep 05, 2021 |
| Title |
Circular RNA Expression and Regulation Profiling in Testicular Tissues of Immature and Mature Wandong Cattle (Bos taurus) |
| Organism |
Bos taurus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Wandong cattle are an autochthonous Chinese breed used extensively for beef production. The breed tolerates extreme weather conditions and raw feed and are resistant to tick-borne diseases. However, the genetic basis of testis development and sperm production as well as breeding management is not well established in local cattle.
In this study, we performed total RNA-Seq and comprehensively analyzed the circ-RNA expression profiling of the testes samples of six bulls at 3 years and 3 months of developmental age. In total, 17 013 circ-RNAs were identified, of which 681 circRNAs (P-adjust < 0.05) were differentially expressed (DE). Among these DE circ-RNAs, 579 were upregulated and 103 were downregulated in calf and bull testes. The Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses revealed that the identified target genes were classified into three broad functional categories, including biological process, cellular component, and molecular function, and were enriched in the lysine degradation, cell cycle, and cell adhesion molecule pathways.
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| Overall design |
Circular RNA experession and regulation in immature and mature local cattle bulls.
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| Contributor(s) |
Khan IM |
| Citation(s) |
34880896 |
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| Submission date |
Sep 03, 2021 |
| Last update date |
Dec 15, 2021 |
| Contact name |
Ibrar Muhammad Khan |
| E-mail(s) |
ibrar.pesh@gmail.com
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| Phone |
13075561865
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| Organization name |
Anhui Agricultural University
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| Department |
Animal Science
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| Street address |
1Anhui Provincial Laboratory of Local Livestock and Poultry Genetical Resource Conservation and Breeding, Collage of Animal Science and Technology, Anhui Agricultural University, Hefei, Anhui, China, 230036
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| City |
Hefei |
| ZIP/Postal code |
230036 |
| Country |
China |
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| Platforms (1) |
| GPL26012 |
Illumina NovaSeq 6000 (Bos taurus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA760322 |
| SRA |
SRP335521 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE183347_anno_genes.FPKM.txt.gz |
1.7 Mb |
(ftp)(http) |
TXT |
| GSE183347_anno_transcripts.FPKM.txt.gz |
3.8 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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