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| Status |
Public on Jan 26, 2022 |
| Title |
RNA molecular signature profiling in PBMCs of sporadic ALS patients: HSP70 overexpression is associated with nuclear SOD1 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
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| Summary |
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease caused by loss of motor neurons. SOD1 may have a toxic role in the pathogenesis of ALS when the protein aggregates in the cytoplasm; increased accumulation of soluble nuclear SOD1 (nSOD1) represents a protective cellular reaction.
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| Overall design |
Peripheral Blood Mononuclear Cells derived from 18 sALS patients and 12 age- and sex-matched healthy controls (CTRL) were deep-sequenced and included in Real Time PCR experiments.
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| Contributor(s) |
Garofalo M, Pandini C, Bordoni M, Jacchetti E, Diamanti L, Carelli S, Raimondi MT, Sproviero D, Crippa V, Carra S, Poletti A, Pansarasa O, Gagliardi S, Cereda C |
| Citation |
https://doi.org/10.3390/cells11020293
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| |
| Submission date |
Sep 01, 2021 |
| Last update date |
Jan 27, 2022 |
| Contact name |
Maria Garofalo |
| E-mail(s) |
maria.garofalo01@universitadipavia.it
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| Organization name |
IRCCS Mondino Foundation
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| Lab |
Genomic and Post Genomic Unit
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| Street address |
Via Mondino 2
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| City |
Pavia |
| ZIP/Postal code |
27100 |
| Country |
Italy |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (30)
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| Relations |
| BioProject |
PRJNA759611 |
| SRA |
SRP335222 |
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