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Series GSE182849 Query DataSets for GSE182849
Status Public on Sep 28, 2022
Title Transcriptomics in olfactory cells transfected with SARS-CoV-2 structural proteins
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary One of the most common symptoms in COVID-19 is a sudden loss of smell. SARS-CoV-2 has been detected in the olfactory bulb (OB) from animal models and sporadically in COVID-19 patients. To decipher the specific role of SARS-CoV-2 proteome at olfactory level, we deeply characterized the molecular imbalance induced by the expression of GFP-tagged SARS-CoV-2 structural proteins (M, N, E, S) on mouse OB cells by RNA-seq.
Overall design mouse OBC1 cells total RNA profile of 5 group of samples: M, E, N, S and control GFP group. Three replicates per sample. Deep sequencing in Illumina HiSeq1500.
Contributor(s) Santamaría E, Lachén-Montes M, Mendizuri N, Kochan G, de Toro M, Fernandez-Irigoyen J, Escors D
Citation(s) 36159830
Submission date Aug 26, 2021
Last update date Sep 29, 2022
Contact name María de Toro
Organization name Centro de Investigación Biomédica de La Rioja
Department Genomics & Bioinformatics Core Facility
Street address C/Piqueras 98
City Logrono
State/province La Rioja
ZIP/Postal code 26006
Country Spain
Platforms (1)
GPL18480 Illumina HiSeq 1500 (Mus musculus)
Samples (15)
GSM5538274 Control sample replicate 1
GSM5538275 Control sample replicate 2
GSM5538276 Control sample replicate 3
BioProject PRJNA758061
SRA SRP334255

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE182849_RAW.tar 13.0 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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