|
| Status |
Public on Aug 17, 2024 |
| Title |
ALKBH5 cooperated with LINC00659 promote gastric cancer progression by JAK1 mRNA m6A-YTHDF2-dependent modification [2-m6A] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
N6-methyladenosine (m6A) modification is the most prevalent RNA epigenetic regulation in eukaryotic cells. Recent studies focused on the association between m6A and non-coding RNAs. The demethylase ALKBH5 acts as critical oncogenes or tumor suppressors through multiple mechanisms in various cancers. Here, we find that ALKBH5 is highly expressed in GC tissues and is associated with poor prognosis. ALKBH5 promoted the proliferation and metastasis both in vitro and in vivo. ALKBH5 was recruited by LINC00659, which removed m6A modifications of JAK1, leading to the upregulated expression of JAK1.Since ALKBH5 and LINC00659 have oncogenic role in gastric cancer (GC) progression with poor prognosis, ALKBH5-LINC00659/m6A/JAK1 axis can be new biological mechanisms behind GC development and future therapeutic opportunities.
|
| |
|
| Overall design |
MeRIP-seq of BGC-823 cells
|
| |
|
| Contributor(s) |
Fang Y, Shu Y |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Aug 21, 2021 |
| Last update date |
Aug 17, 2024 |
| Contact name |
Yuan Fang |
| E-mail(s) |
fangyuannjmu@126.com
|
| Organization name |
The First Affiliated Hospital of Nanjing Medical University
|
| Street address |
guangzhou road
|
| City |
Nanjing |
| ZIP/Postal code |
210029 |
| Country |
China |
| |
|
| Platforms (1) |
|
| Samples (2) |
|
| Relations |
| BioProject |
PRJNA756695 |
| SRA |
SRP333557 |
