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| Status |
Public on Mar 02, 2022 |
| Title |
Qingda granule（QDG） treatment lower Angiotensin-II-induced blood pressure |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The goals of this study is to compare the differently expressed genes in renal tissue of C57BL/6 WT mice with or without Angiotensin II (AngII) treatment as well as differently expressed genes in the renal tissue of WT mice with AngII treatment with or without Qingda granule（QDG）treatment. The mice (n=15) were randomly divided into 3 groups: control, AngII,AngII+ QDG (n=5 for each group). Mice in Control and AngII groups were infused with saline or 500 ng/kg/min of AngII respectively, and intragastrically with double distilled water (dd H2O); while mice in AngII + QDG groups were infused with AngII (500 ng/kg/min) and intragastrically with 1.145 g/kg/D of QDG for 4 weeks. Then the renal tissue were used to identify differentially expressed genes among different groups.
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| Overall design |
RNA sequencing was performed with renal tissue of mice in 3 groups: control, AngII, Qingda granule（QDG） treated (n=5 for each group) to identify the differently expressed genes and related pathway.
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| Contributor(s) |
Peng J, Shen A, Long L, Zhang X |
| Citation(s) |
35222007 |
| |
| Submission date |
Aug 20, 2021 |
| Last update date |
Mar 03, 2022 |
| Contact name |
Jun Peng |
| E-mail(s) |
pjunlab@hotmail.com
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| Organization name |
Fujian University of Traditional Chinese Medicine
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| Department |
Academy of Integrative Medicine
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| Street address |
1 Qiuyang Road, Minhou Shangjie
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| City |
Fuzhou |
| State/province |
Fujian |
| ZIP/Postal code |
350122 |
| Country |
China |
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| Platforms (1) |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA756553 |
| SRA |
SRP333478 |
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