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| Status |
Public on Sep 14, 2021 |
| Title |
ELK3 controls gastric cancer cell migration and invasion by regulating ECM remodeling-related genes |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Current therapeutic strategies, including surgery and chemotherapy, for gastric cancer improve survival; however, the survival rate for those with metastatic gastric cancer is very low. The molecular mechanisms underlying dissemination of gastric cancer cells to distant organs are unknown. Here, we show that the ELK3 gene is necessary for migration and invasion of gastric cancer cells. The ELK3 gene modulates expression of extracellular matrix (ECM) remodeling-related genes such as LOXL2, SERPINF1, COL16A1, NID1, and SNAI1 to facilitate cancer cell dissemination. Our in silico analysis indicated that ELK3 expression was positively correlated with these ECM remodeling-related genes in gastric cancer cells and human gastric cancer patients. High expression of ELK3 and other ECM remodeling-related genes was also closely associated with a worse prognosis of gastric cancer patients. These findings suggested that ELK3 acts as an important regulator of gastric cancer dissemination by regulating ECM remodeling.
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| Overall design |
Gene expression comparison with or without ELK3; between SNU638 wild type and ELK3 knockdown.
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| |
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| Contributor(s) |
Lee M, Cho H, Park K, Jung H |
| Citation(s) |
35409069 |
| |
| Submission date |
Aug 10, 2021 |
| Last update date |
Apr 20, 2022 |
| Contact name |
Minwook Lee |
| E-mail(s) |
minwook1995@gmail.com
|
| Organization name |
CHA University
|
| Street address |
335 Pangyo-ro, Bundang-gu
|
| City |
Seongnam-si |
| State/province |
Gyeonggi |
| ZIP/Postal code |
13488 |
| Country |
South Korea |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA753553 |
| SRA |
SRP331973 |
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