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| Status |
Public on Feb 09, 2022 |
| Title |
Depletion of AUF1 from myeloid cells protects from allergic airway and tumor infiltration and alters pro-angiogenic macrophage polarization by adenosines |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Our data demonstrate that in innate immune cells, AUF1 does not act as a generic anti-inflammatory factor but has a rather distinct role in selective macrophage phenotypes.
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| Overall design |
We use a conditional allele for the myeloid deletion of the hnRNPD gene and employ a disease-oriented phenotypic screen to assess the requirement of AUF1 in contexts of innate immune reactivity.
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| Contributor(s) |
Gargani S, Lourou N, Arapatzi C, Tzanos D, Saridakι M, Dushku E, Chatzimike M, Sidiropoulos ND, Andreadou M, Ntafis V, Hatzis P, Kostourou V, Kontoyiannis DL |
| Citation(s) |
35222366 |
| |
| Submission date |
Jul 30, 2021 |
| Last update date |
Mar 04, 2022 |
| Contact name |
Dimitris L. Kontoyiannis |
| E-mail(s) |
dklab@fleming.gr, kontoyiannis@fleming.gr
|
| Organization name |
BSRC "Alexander Fleming"
|
| Department |
Institute for Fundamental Biomedical Research
|
| Lab |
Dimitris Kontoyiannis lab
|
| Street address |
34 Fleming
|
| City |
Vari |
| State/province |
Attiki |
| ZIP/Postal code |
166 72 |
| Country |
Greece |
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| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA751080 |
| SRA |
SRP330617 |
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