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| Status |
Public on Aug 02, 2021 |
| Title |
Protective heterologous T cell immunity in COVID-19 induced by MMR and Tdap vaccine antigens |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Other
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| Summary |
High correlation was observed between T cell responses to SARS-CoV-2 and MMR and Tdap vaccine proteins in infected and uninfected individuals; the overlapping T cell population contained an effector memory T cell subset previously implicated in protective anti-viral immunity and their activation required APC-derived IL-15, known to sensitize T cells to activation. We were able to detect cross-reactive TCR repertoire in antigen experienced T cells recognizing SARS-CoV-2, MMR and Tdap epitopes using clonotyping and scRNA-seq. Indices of disease severity were reduced in MMR or Tdap vaccinated individuals by 32-38% and 20-23% respectively, among 73.582 COVID-19 positive patients.
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| Overall design |
Total of 12 human samples, T cell samples from 3 controls and 3 patients were analyzed for the study. 3 Control and 3 patient samples were treated with SARS-CoV-2 antigens and 3 samples from patients were treated with MMR and 3 samples were treated with Tdap antigens.
Submitter states "The sequencing was performed by an outside company; we are attempting to locate the fastq files"
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| |
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| Contributor(s) |
Settles ML, Mysore V |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jul 28, 2021 |
| Last update date |
Aug 04, 2021 |
| Contact name |
Monica Britton |
| E-mail(s) |
mtbritton@ucdavis.edu
|
| Organization name |
University of California, Davis
|
| Department |
Genome Center Service Cores
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| Lab |
Bioinformatics Core Facility
|
| Street address |
451 Health Sciences Dr., Rm. 1300
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| City |
Davis |
| State/province |
CA |
| ZIP/Postal code |
95616 |
| Country |
USA |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA750464 |
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