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| Status |
Public on Sep 19, 2023 |
| Title |
Identifying main functional pathways associated with cognitive resilience to Alzheimer ´s Disease |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Understanding the mechanisms involved in cognitive resilience in Alzheimer’s disease (AD) represents a promising strategy to identify novel treatments for dementia in AD. Previous findings from our group revealed that the study of aged-Tg2576 cognitive resilient individuals is a suitable tool for this purpose. Here, by performing a transcriptomic analysis of the prefrontal cortex of demented and resilient Tg2576 mice, we have been able to hypothesize that pathways involved in inflammation, amyloid degradation, memory function and neurotransmission may be playing a role on cognitive resilience in AD. Intriguingly, the results obtained in this study are suggestive of a reduction of the influx of peripheral immune cells into the brain on cognitive resilient subjects. Indeed, Cd4 mRNA expression is significantly reduced on Tg2576 mice with cognitive resilience and interestingly, we have found a negative correlation between CD4 mRNA levels in the periphery and the score in the Mini-Mental State Exam of AD patients. All of this, highlights the importance of understanding the role of the immune system on the development of neurodegenerative diseases and points out to the infiltration of CD4+ cells in the brain as a key player of cognitive dysfunction in AD.
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| Overall design |
Comparison of transcripts in the frontal cortex between good learner (GL) or resilient and poor learner (PL) or memory impaired trasngenic Alzheimer´s disease (AD) mice
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| Contributor(s) |
Cuadrado-Tejedor M, García-Osta A |
| Citation(s) |
34502030 |
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| Submission date |
Jul 27, 2021 |
| Last update date |
Sep 20, 2023 |
| Contact name |
Ana Garcia Osta |
| E-mail(s) |
agosta@unav.es
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| Phone |
9481947002023
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| Organization name |
Cima
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| Department |
neuroscience
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| Lab |
2.06
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| Street address |
Juslarrocha 10, 3H
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| City |
Pamplona |
| State/province |
Navarra |
| ZIP/Postal code |
31540 |
| Country |
Spain |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA750130 |
| SRA |
SRP330100 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE180968_RAW.tar |
21.8 Mb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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