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| Status |
Public on Mar 09, 2022 |
| Title |
Analysis of RA vs 4-oxo-RA gene expression regulation in Xenopus laevis |
| Organism |
Xenopus laevis |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We analyzed anterior halves of NF stage 15 embryos that were treated with 10uM DMSO (control), or 1uM RA and 10uM 4-oxo-RA (experimental) for changes in gene expression induced by the two mophogens. RNA-sequencing revealed significant overlap in genes upregulated by both RA and 4-oxo-RA, and to a lesser extent, those downregulated by them. We report all Zic-1 targets described in accompanying manuscript to be regulated by both RA and 4-oxo-RA.
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| Overall design |
Examination of gene expression changes induced by RA and 4-oxo-RA in anterior regions of neurulating NF stage 15 Xenopus laevis embryos
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| Contributor(s) |
Dubey A, Saint-Jeannet J, Zappile P, Lin Z |
| Citation(s) |
34536327 |
| Submission date |
Jul 16, 2021 |
| Last update date |
Mar 10, 2022 |
| Contact name |
Ziyan Lin |
| E-mail(s) |
ziyanlin2352@gmail.com
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| Organization name |
NYU Grossman School of Medicine
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| Department |
Applied Bioinformatics Laboratories
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| Street address |
227 E 30th St.
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10016 |
| Country |
USA |
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| Platforms (1) |
| GPL17682 |
Illumina HiSeq 2000 (Xenopus laevis) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA747290 |
| SRA |
SRP328713 |
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