|
| Status |
Public on Oct 01, 2022 |
| Title |
Pulmonary epithelial and endothelial cell damage, loss of repair, inhibition of fibrinolysis and cellular senscence in fatal COVID-19 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Key pulmonary findings included: 1) Loss or damage to respiratory epithelial basal cells, alveolar epithelial cells, 2) Impaired clot fibrinolysis with increased levels of plasma and lung PAI-1, and 3) modulation of cellular senescence markers.
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| |
|
| Overall design |
Inregration of lung gene expression and viral load, pathology and plasma protein from autopsy tissue from COVID-19 patients was compared normal lung tissue
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| |
|
| Contributor(s) |
Walters K, Kash JC, Taubenberger JK |
| Citation(s) |
34648357, 35857640 |
| |
| Submission date |
Jul 15, 2021 |
| Last update date |
May 01, 2024 |
| Contact name |
kathie walters |
| E-mail(s) |
kwalters@systemsbiology.org
|
| Organization name |
Institute for Systems Biology
|
| Street address |
401 Terry Ave N
|
| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98109 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6480 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version) |
|
| Samples (23)
|
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| Relations |
| BioProject |
PRJNA747055 |
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