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| Status |
Public on Jul 07, 2022 |
| Title |
RNA demethylase ALKBH5 promotes tumorigenesis in multiple myeloma [m6A-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by high throughput sequencing
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| Summary |
We here report ALKBH5, a m6A RNA demethylase, as a crucial oncogene in multiple myeloma (MM). Using various MM models, we demonstrated a critical requirement of ALKBH5 for MM cell proliferation in vitro and in vivo. To identify the potential mRNA targets of ALKBH5, we conducted m6A-seq with mRNA samples enriched from MM cells with or without ALKBH5 knockdown.
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| Overall design |
m6A-seq of RPMI-8226 cells with or without shRNA-mediated ALKBH5 konckdown
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| Contributor(s) |
Hou Y, Cai Z |
| Citation missing |
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| |
| Submission date |
Jul 15, 2021 |
| Last update date |
Jul 07, 2022 |
| Contact name |
Yifan Hou |
| Organization name |
Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University
|
| Street address |
No. 79, Qingchun Rd
|
| City |
Hangzhou |
| ZIP/Postal code |
310006 |
| Country |
China |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE180215 |
RNA demethylase ALKBH5 promotes tumorigenesis in multiple myeloma |
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| Relations |
| BioProject |
PRJNA747019 |
| SRA |
SRP328553 |
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