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Series GSE180086 Query DataSets for GSE180086
Status Public on Aug 30, 2021
Title Novel Mechanisms of Antibiotic Resistance in Mismatch Repair-Deficient Pseudomonas aeruginosa hypermutators
Organism Pseudomonas aeruginosa
Experiment type Expression profiling by high throughput sequencing
Summary Using in vitro directed evolution, we show that mismatch repair-deficient Pseudomonas aeruginosa can engage novel resistance mechanisms to ceftazidime-avibactam.
 
Overall design Whole-genome and RNA sequencing of P. aeruginosa isolates passaged under ceftazidime/avibactam selection.
 
Contributor(s) Dulanto Chiang A, Patil PP, Beka L, Youn J, Launay AP, Bonomo RA, Khil PP, Dekker JP
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BioProject PRJNA693407
Submission date Jul 14, 2021
Last update date Sep 02, 2021
Contact name Augusto Dulanto Chiang
E-mail(s) dulantoa@nih.gov
Organization name NIAID
Street address 9000 Rockville Pike
City Bethesda
State/province Maryland
ZIP/Postal code 20814
Country USA
 
Platforms (1)
GPL28386 NextSeq 550 (Pseudomonas aeruginosa)
Samples (74)
GSM5452546 RNA-seq of P. aeruginosa CZA-adapted isolates, sample: 1A15_A
GSM5452547 RNA-seq of P. aeruginosa CZA-adapted isolates, sample: 1A15_B
GSM5452548 RNA-seq of P. aeruginosa CZA-adapted isolates, sample: 1A15_C

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE180086_RAW.tar 1.5 Mb (http)(custom) TAR (of TSV)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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