 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Oct 13, 2021 |
| Title |
RNA Sequencing reveals transcriptome profiling of HUVECs in response to NETs ± defibrotide |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We reported the application of RNA sequecing to broadly understand the pathways associated with HUVECs exposed to vehicle, NETs, or NETs + defibrotide. We identified 440 differentially expressed genes (300 upregulated) in HUVECs upon NET stimulation as compared with vehicle. Conversely, there were 229 differentially expressed genes (192 downregulated) when the NETs + defibrotide group was compared to NETs alone.
|
| |
|
| Overall design |
A human umbilic endothelial cell line (ATCC) was cultured and treated with the NET stimulus alone or the NET stimulus plus a drug (defibrotide).
|
| |
|
| Contributor(s) |
Shi H, Knight JS, King DM, Padmanabhan K |
| Citation(s) |
34264868 |
| |
| Submission date |
Jul 09, 2021 |
| Last update date |
Oct 13, 2021 |
| Contact name |
Bioinformatics Core |
| E-mail(s) |
bioinformatics@umich.edu
|
| Organization name |
University of Michigan
|
| Street address |
BRCF Bioinformatics Core, 2800 Plymouth Rd
|
| City |
Ann Arbor |
| State/province |
Mi |
| ZIP/Postal code |
48109-2800 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (9)
|
|
| Relations |
| BioProject |
PRJNA745193 |
| SRA |
SRP327672 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE179828_gene_expected_count.txt.gz |
548.6 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
|
|
|
|
 |
Less...
More...