|
| Status |
Public on Sep 01, 2022 |
| Title |
Targeting epithelial-mesenchymal plasticity via ribosome inhibition to reduce chemoresistant metastasis of breast cancer [bulk RNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Using an EMT lineage-tracing model, we identified tumor cells in the transitioning phases of both EMT and MET. Further analyses revealed that the ribosome biogenesis (RiBi) pathway was specifically elevated in these transitioning cells, regardless of their destined phenotypical fates.
|
| |
|
| Overall design |
mRNA profiling of flow cytometry sorted RFP+, GFP+, and Double+ Tri-PyMT cells. 3 samples of each type of cells were sequenced.
|
| |
|
| Contributor(s) |
Ban Y, Gao D |
| Citation(s) |
39259576 |
| |
| Submission date |
Jun 21, 2021 |
| Last update date |
Oct 08, 2024 |
| Contact name |
Dingcheng Gao |
| E-mail(s) |
dig2009@med.cornell.edu
|
| Organization name |
Weill Cornell Medical College
|
| Department |
CT Surgery
|
| Street address |
1300 York Ave
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10065 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
|
| Samples (9)
|
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| This SubSeries is part of SuperSeries: |
| GSE178579 |
Targeting epithelial-mesenchymal plasticity via ribosome inhibition to reduce chemoresistant metastasis of breast cancer |
|
| Relations |
| BioProject |
PRJNA739680 |
| SRA |
SRP324846 |
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