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| Status |
Public on Jun 12, 2021 |
| Title |
Integrative Analysis of miRNA and gene Expression Profiles of Early-Onset Preeclampsia |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
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| Summary |
To investigate the differentially expressed mRNAs and microRNAs in human placenta between early-onset preeclampsia (EO-PE) and preterm birth controls (PTB), next generation sequencing was performed in 5 paired EO-PE and PTB placentas.
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| Overall design |
The rapid development of gene microarray and next generation sequencing has expedited the understanding of the genetic landscape of PE. While substantial evidence supports differential placental gene expression in PE, few studies were reported to systematically study miRNA and gene expression profiles in PE which should provide new insights into the miRNA-gene regulatory networks during the pathological process of PE. To address this paucity of data, we investigated global placental miRNA and gene expression using high-throughput RNA sequencing and quantitative real-time (qRT)-polymerase chain reaction (PCR) methodologies among 5 EO-PE cases and 5 normotensive preterm control subjects to identify miRNA-gene interaction networks and PE-associated biological pathways.
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| Contributor(s) |
Duan T, Zhao X, Zou G, Zhang D |
| Citation missing |
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| |
| Submission date |
Jun 11, 2021 |
| Last update date |
Jun 12, 2021 |
| Contact name |
Tao Duan |
| E-mail(s) |
duan_taotongji@aliyun.com
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| Organization name |
shanghai first maternity and infant hospital , tongji university school of medicine
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| Department |
obstetrics
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| Street address |
NO.2699, West Gao ke Road, Pudong New District
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| City |
shanghai |
| ZIP/Postal code |
201204 |
| Country |
China |
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| Platforms (2) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (20)
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| Relations |
| BioProject |
PRJNA736971 |
| SRA |
SRP323745 |
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