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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Apr 01, 2022 |
| Title |
Gene expression analysis of murine endometrial cancer cell lines and murine normal endometrium |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Endometrium-specific Cre-Lox deletion of both Pten and Tp53 via regulation of the progesterone receptor promoter is known to generate a spontaneous carcinogenic mouse model of endometrial cancer. A mouse endometrial cancer cell line, mECC, was established from the uterine carcinoma tumor tissue of its pure strain model generated by backcrossing in C57BL/6 mice. A high-grade endometrial cancer cell line (Highly Progressive mECC: HPmECC) was established by further introducing c-Myc in mECCs. RNA sequencing analysis was performed using cultured HPmECCs and mECCs, as well as primary cultured C57BL/6 normal endometrial cells for assessing the genetic characteristics of HPmECCs.
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| Overall design |
RNA-Seq in murine endometrial cancer cell-lines from C57BL/6 mice with or without overexpressed Myc and normal C57BL/6 mice endometrium.
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| Contributor(s) |
Mise Y, Baba T |
| Citation(s) |
35353883 |
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| Submission date |
Jun 07, 2021 |
| Last update date |
Jun 27, 2022 |
| Contact name |
mise yuka |
| E-mail(s) |
ymtm@kuhp.kyoto-u.ac.jp
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| Organization name |
Kyoto University Graduate School of Medicine
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| Department |
Gynecology and Obstetrics
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| Street address |
54 Kawahara-cho, Shogoin, Sakyo-ku,
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| City |
Kyoto |
| ZIP/Postal code |
606-8507 |
| Country |
Japan |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (12)
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| GSM5360737 |
primary cultured normal endometrium cells, B6-1 |
| GSM5360738 |
primary cultured normal endometrium cells, B6-2 |
| GSM5360739 |
primary cultured normal endometrium cells, B6-3 |
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| Relations |
| BioProject |
PRJNA735644 |
| SRA |
SRP322977 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE176257_Mise_202003_fpkm.txt.gz |
690.8 Kb |
(ftp)(http) |
TXT |
| GSE176257_Mise_202003_read_counts.txt.gz |
560.7 Kb |
(ftp)(http) |
TXT |
| GSE176257_Mise_202003_tpm.txt.gz |
719.6 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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