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| Status |
Public on Aug 25, 2021 |
| Title |
Fibroblast growth factor receptor 3 in hepatocytes protects from liver injury and fibrosis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
ABSTRACT. The liver has a remarkable regenerative capacity, which is orchestrated by several growth factors and cytokines. We generated mice lacking Fgfr3 in hepatocytes and found increased liver injury and enhanced fibrosis in these animals. To unravel the underlying mechanisms we sequenced the RNA from isolated hepatocytes of Fgfr3 knockout and control mice and identifed differentially expressed genes involved in metabolic regulation, immune regulation and fibrosis.
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| Overall design |
Alb-Cre mice and mice lacking Fgfr3 (Alb-R3) specifically in hepatocytes, were subjected to CCl4 or oil treatment for 48 hours and gene expression profiling was determined using RNA-seq
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| Contributor(s) |
Fearon AE, Slabber CF, Kuklin A, Werner S |
| Citation(s) |
34646985 |
| |
| Submission date |
Jun 07, 2021 |
| Last update date |
Oct 19, 2021 |
| Contact name |
Sabine Werner |
| E-mail(s) |
sabine.werner@biol.ethz.ch
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| Organization name |
ETH Zurich
|
| Department |
Department of Biology
|
| Street address |
Otto-Stern-Weg 7
|
| City |
Zurich |
| ZIP/Postal code |
8093 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA735641 |
| SRA |
SRP322975 |
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