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| Status |
Public on Oct 04, 2021 |
| Title |
Innate immunity-driven cell recruitment in rat autoimmune diabetes |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Comparative analysis of the response of wild-type (WT) and Ifnar1 knockout LEW.1WR1 rats to infection with Kilham rat virus (KRV) using the Seq-Well single-cell RNA-Seq method. KRV induces the equivalent of human type I diabetes (T1D) in WT rats.
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| Overall design |
Seq-Well single-cell RNA-Seq analysis of wild-type and Ifnar1 knockout LEW.1WR1 rats infected with Kilham rat virus.
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| Contributor(s) |
Qaisar N, Arowosegbe A, Derr AG, Kucukural A, Trombly MI, Satish B, Racicot R, Guo Z, Wang JP |
| Citation(s) |
34702762 |
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| Submission date |
Jun 03, 2021 |
| Last update date |
May 26, 2022 |
| Contact name |
Alan G Derr |
| E-mail(s) |
alan.derr@umassmed.edu
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| Organization name |
University of Massachusetts Medical School
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| Department |
Program in Bioinformatics and Integrative Biology
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| Lab |
Garber Lab
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| Street address |
55 Lake Ave North
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| City |
Worcester |
| State/province |
Massachusetts |
| ZIP/Postal code |
01655 |
| Country |
USA |
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| Platforms (1) |
| GPL20084 |
Illumina NextSeq 500 (Rattus norvegicus) |
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| Samples (20)
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| GSM5354589 |
wild-type spleen, day 1, Seq-Well plate 1 |
| GSM5354590 |
wild-type spleen, day 1, Seq-Well plate 2 |
| GSM5354591 |
wild-type spleen, day 1, Seq-Well plate 3 |
| GSM5354592 |
wild-type spleen, day 1, Seq-Well plate 4 |
| GSM5354593 |
wild-type spleen, day 1, Seq-Well plate 5 |
| GSM5354594 |
wild-type spleen, day 5, Seq-Well plate 1 |
| GSM5354595 |
wild-type spleen, day 5, Seq-Well plate 2 |
| GSM5354596 |
wild-type spleen, day 5, Seq-Well plate 3 |
| GSM5354597 |
wild-type spleen, day 5, Seq-Well plate 4 |
| GSM5354598 |
wild-type spleen, day 5, Seq-Well plate 5 |
| GSM5354599 |
Ifnar1-KO spleen, day 3, Seq-Well plate 1 |
| GSM5354600 |
Ifnar1-KO spleen, day 3, Seq-Well plate 2 |
| GSM5354601 |
Ifnar1-KO spleen, day 3, Seq-Well plate 3 |
| GSM5354602 |
Ifnar1-KO spleen, day 3, Seq-Well plate 4 |
| GSM5354603 |
Ifnar1-KO spleen, day 3, Seq-Well plate 5 |
| GSM5354604 |
Ifnar1-KO spleen, day 7, Seq-Well plate 1 |
| GSM5354605 |
Ifnar1-KO spleen, day 7, Seq-Well plate 2 |
| GSM5354606 |
Ifnar1-KO spleen, day 7, Seq-Well plate 3 |
| GSM5354607 |
Ifnar1-KO spleen, day 7, Seq-Well plate 4 |
| GSM5354608 |
Ifnar1-KO spleen, day 7, Seq-Well plate 5 |
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| Relations |
| BioProject |
PRJNA734852 |
| SRA |
SRP322428 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE176082_Ifnar_KO_exp_phenotype.txt.gz |
121.9 Kb |
(ftp)(http) |
TXT |
| GSE176082_Ifnar_KO_exp_rawCounts.txt.gz |
4.3 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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