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Series GSE174840 Query DataSets for GSE174840
Status Public on Dec 14, 2021
Title Examining Pathogenesis in Genome Instability Associated Neurodegenerative Mouse Model [TotalStranded-RNA-seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary To investigate the molecular basis for ataxia in the DNA repair deficient mice we utilized RNA-seq to evaluate the transcriptome of AtmNes-cre;Aptx-/- (and AtmNes-cre;Parp1-/-) cerebellar and cortical tissue. Using total RNA from symptomatic 10-month-old double-mutant mice and littermate controls, we performed the transcriptome analysis. top 1,000 expressed genes in each genotype
 
Overall design Total Stranded RNA sequencing of the cerebellum and cortex examining gene expression in ATM APTX null and associated control brains.
 
Contributor(s) Shaw T, Jin H, Kwak Y
Citation(s) 34910524
Submission date May 21, 2021
Last update date Mar 15, 2022
Contact name Peter J McKinnon
Organization name St. Jude Children's Research Hospital
Department Center for Pediatric Neurological Disease Research
Lab McKinnon Lab
Street address 262 Danny Thomas Place
City Memphis
State/province Tennessee
ZIP/Postal code 38105
Country USA
 
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (24)
GSM5329073 Total Stranded RNA-sequencing_APTXATM_CB_1
GSM5329074 Total Stranded RNA-sequencing_APTXATM_CB_2
GSM5329075 Total Stranded RNA-sequencing_APTXATM_CB_3
This SubSeries is part of SuperSeries:
GSE174842 Examining Pathogenesis in Genome Instability Associated Neurodegenerative Mouse Model
Relations
BioProject PRJNA731881
SRA SRP320863

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE174840_TotalStranded_FPKM_Cerebellum.xlsx 3.5 Mb (ftp)(http) XLSX
GSE174840_TotalStranded_FPKM_Cortex.xlsx 2.7 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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